2023

public technical reports

Optimization and evaluation of pipeline for practical use concluded

Seamless integration of electrophysiological data workflows with TVB modelling

Multi-resolution TVB models with evidence for optimal granularity

CTS2 standard compliant interface will be released to project partners

Publication of a causality study based on an instrumental variables approach

TVB human models will be made available. We will identify the biophysical terms in the TVB models that are altered in NDD as compared to healthy individuals, and in relation to cognitive status

Validated Use Case of a brain simulation platform for NDD, usable by scientists and clinicians, for subsequent refined clinical studies towards development of therapeutic targets associated with basic physiological mechanisms

2022

public technical reports

Webinar with demonstration of personalized simulation (“case studies”) using the integrated model in TVB

Workflows established that link progression models and TVB

Final VBC platform is fully integrated and validated and full documentation of its functionalities

Validated and benchmarked data fitting workflow will be provided as a software for brain model personalization

Final analysis of relevant legal, ethical and regulatory framework, 2nd iteration, including a report on best practices and industry standards

2021

public technical reports

Most appropriate RS-processing pipelines for TVB modelling finished

Group level SEEG brain dynamics measures and analysis pipeline for SEEG

Full-cohort individual MEG brain dynamics measures at the disposal

Framework for multi-modal integrated annotations established and in use

Evaluation and optimization of pipeline for practical use concluded

Publication of a study on deconfounding for inference

Semantically enhanced multi-viewer that embeds a newly developed TVB 3D viewer

A functionally integrated version of VBC is evaluated for therapeutical targets

VBC operation report and published services on EOSC/EGI Marketplace

2020

public technical reports

Gateway to PRACE documentation and guidelines

Paper manuscript describing the initial characterization of the studies, the equivalence of their variables and the summary statistics

Semantic framework for neurodegeneration research documented

Integrated, open source terminology versioning and management tool CTS2 compliant application

Initial version of full-scope containerized pipeline developed

Full-cohort MEG time series in BIDS share and analysis pipeline ready

Evaluation of cross-modal atlas-based compression for machine-learning

Data catalogue with harmonized annotations at project

Text mining workflow to use ontologies and terminologies in OLS for information extraction of “cause-and-effect” statements.

Digital atlas that maps signalling pathways on corresponding brain regions for different neurodegenerative states in humans

2019

public technical reports

Cloud implementation strategy applying “trusted cloud principles”

Interim source-space, multiresolution MEG time series in BIDS share. Initial MEG and SEEG brain dynamics measures.